Order NO. C650037
小鼠抗P16单克隆抗体
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| C650037-0100 | 100UG | 预计7日内发货 |
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| C650037-0500 | 500UG | 预计7日内发货 |
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产品描述
应用
immunohistochemistry：anti-P16 mouse monoclonal antibody.human tonsil tissue and cervical cancer tissue.
组分
1 mg/ml
适用样本
Human
属性
| Background | This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. |
| Product name | Anti-P16 mouse monoclonal antibody |
| Description | Mouse monoclonal antibody to P16 |
| Host species | Mouse |
| Tested applications | IHC |
| Reactivity | Human |
| Immunogen | Recombinant protein. The exact sequence is proprietary. |
| Clone number | SG201876m |
| Isotype | IgG2a |
| Purification | Protein A/G affinity column |
| Uniprot ID | P42771 |
相关文档
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Sample Application
