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Order NO. C650061
小鼠抗AR 单克隆抗体
英文名 Anti-AR mouse monoclonal antibody
相关类别 IVD抗体原料 储存 冷冻（-20℃） 参照组件的存储要求
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
C650061-0100 100UG 预计7日内发货 待询价 待询价
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C650061-0500 500UG 预计7日内发货 待询价 待询价
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产品描述

应用

immunohistochemistry：anti-AR mouse monoclonal antibody

组分

1 mg/ml

适用样本

Human

属性

Background The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.
Product name Anti-AR mouse monoclonal antibody
Description Mouse monoclonal antibody to AR
Host species Mouse
Tested applications IHC
Reactivity Human
Immunogen Recombinant protein. The exact sequence is proprietary.
Clone number SG200076m
Isotype IgG2b
Purification Protein A/G affinity column
Uniprot ID P10275
相关文档
Sample Application

  • IHC image of AR staining in a formalin fixed, paraffin embedded human prostatic cancer tissue. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer for 20 minutes. The tissue section was then incubated with mouse anti-AR (C650061) antibody overnight at 4°C.HRP-conjugated goat anti-Mouse IgG was used as secondary antibody. (Original magnification: 100X).