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Order NO. D121399
兔抗PPM1D多克隆抗体
英文名 Anti-PPM1D rabbit polyclonal antibody
别名 protein phosphatase, Mg2+/Mn2+ dependent 1D WIP1; PP2C-DELTA
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse
克隆类型 rabbit polyclonal 抗原 PPM1D
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D121399-0025 25 ul 现货
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D121399-0100 100 ul 现货
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D121399-0200 200 ul 现货
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产品描述

概述

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

应用

酶联免疫吸附测定(ELISA),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 O15297
靶点基因 ID 8493
靶点全称 protein phosphatase, Mg2+/Mn2+ dependent 1D
靶点别名 WIP1; PP2C-DELTA
靶点研究领域 Signal Transduction, Cancer
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image is immunohistochemistry of paraffin-embedded Human brain tissue using D121399(PPM1D Antibody) at dilution 1/60. (Original magnification: ×200)

  • The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using D121399(PPM1D Antibody) at dilution 1/60. (Original magnification: ×200)
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