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| 编 号 | 规格 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D121399-0025 | 25 ul | 现货 | 待询价 | 待询价 | |
| D121399-0100 | 100 ul | 现货 | 待询价 | 待询价 | |
| D121399-0200 | 200 ul | 现货 | 待询价 | 待询价 |
概述
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | O15297 |
| 靶点基因 ID | 8493 |
| 靶点全称 | protein phosphatase, Mg2+/Mn2+ dependent 1D |
| 靶点别名 | WIP1; PP2C-DELTA |
| 靶点研究领域 | Signal Transduction, Cancer |
| 亚型 | Immunogen-specific rabbit IgG |
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