Order NO. D124600
产品描述
概述
CNOT10 is a subunit of the CCR4-NOT complex which consists of at least five other CNOT subunit proteins and TAB182. The CCR4-NOT complex is an evolutionarily conserved, multi-component complex known to be involved in transcription, as well as in mRNA degradation. Various subunits (e.g. CNOT1, CNOT3) are uniquely involved in influencing nuclear hormone receptor activities. In effect, this complex has an important role as a transcription regulator and repressor of nuclear receptor signaling that is relevant to the molecular pathways involved in cancer. The CCR4-NOT complex is also involved in the regulation of Histone H3 lysine 4 methylation through a ubiquitin-dependent pathway that likely involves the proteasome.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q9H9A5
|
| 靶点基因 ID |
25904
|
| 靶点全称 |
CCR4-NOT transcription complex subunit 10
|
| 靶点研究领域 |
Epigenetics and Nuclear Signaling
|
| 亚型 |
Immunogen-specific rabbit IgG
|
