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Order NO. D125968
兔抗DHX58多克隆抗体
英文名 Anti-DHX58 rabbit polyclonal antibody
别名 DExH-box helicase 58; LGP2; RLR-3; D11LGP2; D11lgp2e
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Rat
克隆类型 rabbit polyclonal 抗原 DHX58
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D125968-0025 25 ul 现货
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D125968-0100 100 ul 现货
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D125968-0200 200 ul 现货
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产品描述

概述

Acts as a regulator of DDX58/RIG-I and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to DDX58/RIG-I and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on DDX58/RIG-I signaling may involve the following mechanisms: competition with DDX58/RIG-I for binding to the viral RNA, binding to DDX58/RIG-I and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by DDX58/RIG-I and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q96C10
靶点基因 ID 79132
靶点全称 DExH-box helicase 58
靶点别名 LGP2; RLR-3; D11LGP2; D11lgp2e
靶点研究领域 Epigenetics and Nuclear Signaling, Immunology
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: A549 cell, Rat liver tissue, 293T cell lysates, Primary antibody: D125968(DHX58 Antibody) at dilution 1/900, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute
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