概述

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Several transcript variants encoding distinct isoforms have been identified for this gene. It is possible that distinct isoforms of beta chain have different cellular localizations and interact differently with calmodulin. Alternative splicing results in multiple transcript variants. Distinct isoforms of this chain have different expression patterns.

应用

免疫印迹（WB），免疫组织化学（IHC）

属性