Order NO. D161024
产品描述
概述
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
应用
酶联免疫吸附测定（ELISA），免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q00653
|
| 靶点基因 ID |
4791
|
| 靶点全称 |
nuclear factor kappa B subunit 2
|
| 靶点别名 |
p52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; p49/p100
|
| 靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling
|
| 亚型 |
Immunogen-specific rabbit IgG
|
