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编 号 | 包装 | 库存 | 目录价(¥) | 您的价格(¥) | 数 量 |
D164233-0025 | 25 ul | 现货 |
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D164233-0100 | 100 ul | 现货 |
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D164233-0200 | 200 ul | 现货 |
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概述
The Interferon family of proteins are able to alter the expression of a variety of target genes, thereby controlling various events within the cell. IFI-35 (Interferon-induced 35 kDa protein), also known as IFP35, is a 286 amino acid interferon-induced protein. Localized to the nucleus and expressed in macrophages, fibroblasts and epithelial cells, IFI-35 is a leucine zipper protein that can form homodimers, but, unlike most leucine zipper proteins, cannot bind DNA. Upon induction by IFN-α, IFI-35 associates with Nmi (N-Myc-interacting protein), resulting in the formation of a high molecular weight complex that is thought to play a role in IFN-α signaling and cellular responses. Once complexed with Nmi, IFI-35 is unable to be degraded by the proteasome, suggesting that IFI-35 is protected from degradation only when needed by IFN-α. Two isoforms of IFI-35 exist due to alternative splicing events.
应用
酶联免疫吸附测定(ELISA),免疫组织化学(IHC)
属性
保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
运输条件 | 2-8°C |
靶点 Uniprot 登记号 | P80217 |
靶点基因 ID | 3430 |
靶点全称 | interferon induced protein 35 |
靶点别名 | IFP35 |
靶点研究领域 | Cancer |
亚型 | Immunogen-specific rabbit IgG |