Order NO. D194634
产品描述
概述
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.
应用
免疫印迹(WB),免疫荧光(IF),流式细胞术(FCM)
属性
保存缓冲液 |
-20°C, PBS (PH 7.4) containing 0.05% sodium azide.
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P06213
|
靶点基因 ID |
3643
|
靶点全称 |
insulin receptor
|
靶点别名 |
HHF5; CD220
|
靶点研究领域 |
Signal Transduction, Cancer, Metabolism, Neuroscience, Cardiovascular
|
亚型 |
IgG2a
|