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Order NO. D194634
小鼠抗INSR单克隆抗体
英文名 Anti-INSR mouse monoclonal antibody
别名 insulin receptor; HHF5; CD220
相关类别 一抗 储存 冷冻(-20℃)
宿主 Mouse 反应种属 Human, Mouse, Monkey
克隆类型 mouse monoclonal 抗原 INSR
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D194634-0050 50 ul 预计5日内发货
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D194634-0100 100 ul 预计5日内发货
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产品描述

概述

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

应用

免疫印迹(WB),免疫荧光(IF),流式细胞术(FCM)

属性

保存缓冲液 -20°C, PBS (PH 7.4) containing 0.05% sodium azide.
运输条件 2-8°C
靶点 Uniprot 登记号 P06213
靶点基因 ID 3643
靶点全称 insulin receptor
靶点别名 HHF5; CD220
靶点研究领域 Signal Transduction, Cancer, Metabolism, Neuroscience, Cardiovascular
亚型 IgG2a
相关文档
Sample Application

  • The image is flow cytometry analysis of HL-60 cells using D194634(INSR antibody) at dilution 1/400 (green) and negative control (red).

  • The image is immunofluorescence of Hela cells using D194634(INSR Antibody) at dilution 1/200 (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.

  • Gel: 6%SDS-PAGE, Lysate: 20 μg, Lane 1-8: HepG2, HEK293, Jurkat, Hela, THP-1, NIH/3T3, COS-7 and PC-3 cell lysates, Primary antibody: D194634(INSR Antibody) at dilution 1/1000, Secondary antibody: HRP-conjugated Goat anti mouse IgG at 1/10000 dilution, Exposure time: 2 minutes
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