Order NO. D197138
产品描述
概述
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
应用
免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 |
PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q07812
|
| 靶点基因 ID |
581
|
| 靶点全称 |
BCL2 associated X, apoptosis regulator
|
| 靶点别名 |
BCL2L4
|
| 靶点研究领域 |
Cancer
|
| 亚型 |
IgG2b
|
