Order NO. D224167
产品描述
概述
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q8IWX7
|
靶点基因 ID |
146862
|
靶点全称 |
unc-45 myosin chaperone B
|
靶点别名 |
CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B
|
靶点研究领域 |
Signal Transduction, Developmental Biology
|
亚型 |
Immunogen-specific rabbit IgG
|