兔抗ARHGAP45多克隆抗体,Anti-ARHGAP45 rabbit polyclonal antibody 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. D264144

兔抗ARHGAP45多克隆抗体

英文名	Anti-ARHGAP45 rabbit polyclonal antibody
别名	Rho GTPase activating protein 45; HA-1; HMHA1; HLA-HA1
相关类别	一抗	储存	冷冻（-20℃）
宿主	Rabbit	反应种属	Human
克隆类型	rabbit polyclonal	抗原	ARHGAP45
在线咨询

编号	规格	库存	目录价（￥）	您的价格（￥）	数量
D264144-0025	25 ul	现货	待询价	待询价
D264144-0100	100 ul	现货	待询价	待询价
D264144-0200	200 ul	现货	待询价	待询价

产品描述

概述

Contains a GTPase activator for the Rho-type GTPases (RhoGAP) domain that would be able to negatively regulate the actin cytoskeleton as well as cell spreading. However, also contains N-terminally a BAR-domin which is able to play an autoinhibitory effect on this RhoGAP activity. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.

应用

酶联免疫吸附测定（ELISA），免疫组织化学（IHC）

属性

保存缓冲液	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件	2-8°C
靶点 Uniprot 登记号	Q92619
靶点基因 ID	23526
靶点全称	Rho GTPase activating protein 45
靶点别名	HA-1; HMHA1; HLA-HA1
靶点研究领域	Immunology
亚型	Immunogen-specific rabbit IgG