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Order NO. D363307
兔抗CD274多克隆抗体
英文名 Anti-CD274 rabbit polyclonal antibody
别名 CD274 molecule; B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse
克隆类型 rabbit polyclonal 抗原 CD274
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D363307-0025 25 ul 现货
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D363307-0100 100 ul 现货
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D363307-0200 200 ul 现货
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产品描述

概述

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q9NZQ7
靶点基因 ID 29126
靶点全称 CD274 molecule
靶点别名 B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1
靶点研究领域 Immunology, Cancer
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: 231, Raji, RAW264.7, NIH/3T3, HepG2, K562 cell lysates, Primary antibody: D363307(CD274 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 30 seconds
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