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Order NO. D660236
CCND1 抗原（多肽片段）
英文名 CCND1 Antigen (Peptide fragment)
相关类别 抗原 储存 冷冻（-20℃）
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D660236-0001 1 MG 预计30日内发货 待询价 待询价
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产品描述

概述

Synthetic peptide corresponding to a region derived from 255-270 amino acids of human Cyclin D1

属性

Full name Cyclin D1
Synonyms BCL1, PRAD1, U21B31, D11S287E
Swissprot P24385
Gene Accession BC000076
Background The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
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