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Order NO. D662350
TG 抗原（多肽片段）
英文名 TG Antigen (Peptide fragment)
相关类别 抗原 储存 冷冻（-20℃）
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D662350-0001 1 MG 预计30日内发货 待询价 待询价
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产品描述

概述

Synthetic peptide corresponding to a region derived from 2754-2768 amino acids of human thyroglobulin

属性

Full name thyroglobulin
Synonyms TGN; AITD3
Swissprot P01266
Gene Accession NP_003226
Background Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis.
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