Order NO. C521030
产品描述
概述
Recombinant Human Fumarase is produced by our E.coli expression system and the target gene encoding Ala45-Lys510 is expressed.
使用说明
This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
属性
Tag |
None
|
种属 |
Human
|
表达系统 |
E.coli
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Accession# |
P07954
|
Source |
E.coli
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Formulation_Description |
Supplied as a 0.2 μm filtered solution of 20mM Tris, pH 8.0.
|
Storage |
Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
|
Purity |
Greater than 95% as determined by reducing SDS-PAGE.
|
Endotoxin |
Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
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Background |
Fumarase is an enzyme that catalyze the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.
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