重组人PTPRN（687-979）, N-6His, E.coli,Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N (687-979), N-6His, E.coli 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C521770

重组人PTPRN（687-979）, N-6His, E.coli

英文名	Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N (687-979), N-6His, E.coli
相关类别	其他重组蛋白	储存	冷冻（-20℃）

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C521770-0010	10 UG	预计10日内发货
C521770-0050	50 UG	预计10日内发货

产品描述

概述

Recombinant Human Islet Cell Antigen 2/Protein Tyrosine Phosphatase Receptor-type N is produced by our E.coli expression system and the target gene encoding Met687-Gln979 is expressed with a 6His tag at the N-terminus.

使用说明

This material is offered by Sangon Biotech for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.

属性

Tag	N-6His
种属	Human
表达系统	E.coli
Accession#	Q16849
Source	E.coli
Formulation_Description	Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0.
Storage	Store at < -20°C, stable for 6 months after receipt.Please minimize freeze-thaw cycles.
Purity	Greater than 95% as determined by reducing SDS-PAGE.
Endotoxin	Less than 0.1 ng/μg (1 EU/μg) as determined by LAL test.
Background	Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase domain, is expressed in neuroendocrine cells only. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. It implicated in neuroendocrine secretory processes. It may be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. It seems to lack intrinsic enzyme activity, may play a role in the regulation of secretory granules via its interaction with SNTB2. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.