小鼠抗P53单克隆抗体,Anti-P53 mouse monoclonal antibody 生命科学产品与技术服务-生工生物工程(上海)股份有限公司

Order NO. C650012

小鼠抗P53单克隆抗体

英文名	Anti-P53 mouse monoclonal antibody
相关类别	最新产品 IVD抗体原料	储存	冷冻（-20℃）参照组件的存储要求

编号	包装	库存	目录价（￥）	您的价格（￥）	数量
C650012-0100	100UG	预计7日内发货
C650012-0500	500UG	预计7日内发货

产品描述

应用

immunohistochemistry：anti-P53 mouse monoclonal antibody

组分

1 mg/ml

适用样本

Human

属性

Background	This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Product name	Anti-P53 mouse monoclonal antibody
Description	Mouse monoclonal antibody to P53
Host species	Mouse
Tested applications	ELISA, IHC-P
Reactivity	Human
Immunogen	Recombinant protein. The exact sequence is proprietary.
Clone number	4G5
Isotype	IgG1
Purification	Protein A/G affinity purification
Uniprot ID	P04637
Background	This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Product name	Anti-P53 mouse monoclonal antibody
Description	Mouse monoclonal antibody to P53
Host species	Mouse
Tested applications	ELISA, IHC-P
Reactivity	Human
Immunogen	Recombinant protein. The exact sequence is proprietary.
Clone number	4G5
Isotype	IgG1
Purification	Protein A/G affinity purification
Uniprot ID	P04637
Background	This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Product name	Anti-P53 mouse monoclonal antibody
Description	Mouse monoclonal antibody to P53
Host species	Mouse
Tested applications	ELISA, IHC-P
Reactivity	Human
Immunogen	Recombinant protein. The exact sequence is proprietary.
Clone number	4G5
Isotype	IgG1
Purification	Protein A/G affinity purification
Uniprot ID	P04637
Background	This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity.
Product name	Anti-P53 mouse monoclonal antibody
Description	Mouse monoclonal antibody to P53
Host species	Mouse
Tested applications	ELISA, IHC-P
Reactivity	Human
Immunogen	Recombinant protein. The exact sequence is proprietary.
Clone number	4G5
Isotype	IgG1
Purification	Protein A/G affinity purification
Uniprot ID	P04637