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Order NO. C650053
小鼠抗WT1单克隆抗体
英文名 Anti-WT1 mouse monoclonal antibody
相关类别 IVD抗体原料 储存 冷冻(-20℃) 参照组件的存储要求
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
C650053-0100 100UG 预计7日内发货
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C650053-0500 500UG 预计7日内发货
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产品描述

应用

immunohistochemistry:anti-WT1 mouse monoclonal antibody

组分

1 mg/ml

适用样本

Human

属性

Background This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated.
Product name Anti-WT1 mouse monoclonal antibody
Description Mouse monoclonal antibody to WT1
Host species Mouse
Tested applications IHC
Reactivity Human
Immunogen Recombinant protein. The exact sequence is proprietary.
Clone number SG201706m
Isotype IgG2b
Purification Protein A/G affinity column
Uniprot ID P19544
相关文档
Sample Application

  • IHC image of WT1 staining in a formalin fixed, paraffin embedded human Ovarie cancer tissue (left) and kidney tissue (right). The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer for 20 minutes. The tissue section was then incubated with mouse anti-WT1 (C650053) antibody overnight at 4°C.HRP-conjugated goat anti-Mouse IgG was used as secondary antibody. (Original magnification: 100X).

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