Order NO. D111413
癌抗原125（CA125）
| 英文名 | Cancer Antigen 125 (CA125) | ||
| 别名 | mucin 16, cell surface associated; CA125; Cancer Antigen 125; Carbohydrate Antigen; 癌抗原125; 糖链抗原125 | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D111413-0010 | 10 KU | 预计5日内发货 |
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| D111413-0050 | 50 KU | 预计5日内发货 |
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产品描述
概述
Human Cancer Antigen 125 (CA125)
属性
| Full name: | mucin 16, cell surface associated |
| Synonyms: | CA125; CA 125; Cancer Antigen 125; Carbohydrate Antigen 125 |
| Swissprot: | Q8WXI7 |
| Research areas: | Cell Markers, Signal Transduction, Cancer |
| Background: | This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. |
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