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Order NO. D120134
兔抗NFKB1多克隆抗体
英文名 Anti-NFKB1 rabbit polyclonal antibody
别名 nuclear factor kappa B subunit 1; p50; KBF1; p105; EBP-1; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human
克隆类型 rabbit polyclonal 抗原 NFKB1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D120134-0025 25 ul 现货 500 500
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D120134-0100 100 ul 现货 1600 1600
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D120134-0200 200 ul 现货 2500 2500
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产品描述

概述

This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P19838
靶点基因 ID 4790
靶点全称 nuclear factor kappa B subunit 1
靶点别名 KBF1; EBP-1; NF-kB; CVID12; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B1; NF-kappabeta
靶点研究领域 Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Immunology
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using D120134(NFKB1 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: ×200)


  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody: D120134(NFKB1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes

  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using D120134(NFKB1 Antibody) at dilution 1/80, on the right is treated with fusion protein. (Original magnification: ×200)


  • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane: Raji cell lysate, Primary antibody: D120134(NFKB1 Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 2 minutes
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