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Order NO. D121356
兔抗TRAF2多克隆抗体
英文名 Anti-TRAF2 rabbit polyclonal antibody
别名 TRAP; TRAP3; MGC:45012
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse
克隆类型 rabbit polyclonal 抗原 TRAF2
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D121356-0025 25 ul 现货
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D121356-0100 100 ul 现货
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D121356-0200 200 ul 现货
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产品描述

概述

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q12933
靶点基因 ID 7186
靶点全称 TNF receptor associated factor 2
靶点别名 TRAP; TRAP3; RNF117; MGC:45012
靶点研究领域 Signal Transduction, Cancer, Cardiovascular
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using D121356(TRAF2 Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: LO2, HepG2 cell lysates, Primary antibody: D121356(TRAF2 Antibody) at dilution 1/400, Secondary antibody: D110058(HRP-conjugated Goat anti rabbit IgG) at 1/5000 dilution, Exposure time: 1 minute
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