网 站
反 馈
网 站
指 南
Order NO. D122220
兔抗DDIT4多克隆抗体
英文名 Anti-DDIT4 rabbit polyclonal antibody
别名 Dig2; REDD1; REDD-1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 DDIT4
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D122220-0025 25 ul 现货
加入购物车
D122220-0100 100 ul 现货
加入购物车
D122220-0200 200 ul 现货
加入购物车
产品描述

概述

REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.

应用

酶联免疫吸附测定(ELISA),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q9NX09
靶点基因 ID 54541
靶点全称 DNA-damage-inducible transcript 4
靶点别名 Dig2; REDD1; REDD-1
靶点研究领域 Cardiovascular, Cancer, Metabolism
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using D122220(DDIT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)


  • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using D122220(DDIT4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)

    我的购物车(0) 结算