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Order NO. D123289
兔抗TBP多克隆抗体
| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D123289-0025 | 25 ul | 现货 |
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| D123289-0100 | 100 ul | 现货 |
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| D123289-0200 | 200 ul | 现货 |
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属性
| Background: | Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 25-42, and expansion of the number of repeats to 45-66 increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2016] (The background information is obtained from official databases and does not represent the product information.) |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | TBP |
| Immunogen: | Recombinant protein of human TBP |
| Full name: | TATA-box binding protein |
| Synonyms: | HDL4; TBP1; GTF2D; SCA17; TFIID; GTF2D1 |
| SwissProt: | P20226 |
| ELISA Recommended dilution: | 5000-10000 |
| IHC positive control: | Human esophagus cancer |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 38 kDa |
| WB Positive control: | Hela, 293T cell lysates |
| WB Recommended dilution: | 1000-5000 |
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