Order NO. D123653
兔抗HIF1AN多克隆抗体
| 英文名 | Anti-HIF1AN rabbit polyclonal antibody | ||
| 别名 | FIH1 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse |
| 克隆类型 | rabbit polyclonal | 抗原 | HIF1AN |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D123653-0025 | 25 ul | 现货 |
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| D123653-0100 | 100 ul | 现货 |
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| D123653-0200 | 200 ul | 现货 |
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产品描述
概述
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively.
应用
酶联免疫吸附测定（ELISA），免疫印迹（WB），免疫组织化学（IHC）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | Q9NWT6 |
| 靶点基因 ID | 55662 |
| 靶点全称 | hypoxia inducible factor 1, alpha subunit inhibitor |
| 靶点别名 | FIH1 |
| 靶点研究领域 | Cardiovascular, Epigenetics and Nuclear Signaling |
| 亚型 | Immunogen-specific rabbit IgG |
相关文档
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Sample Application
