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Order NO. D126174
兔抗CCDC134多克隆抗体
英文名 Anti-CCDC134 rabbit polyclonal antibody
别名 coiled-coil domain containing 134
相关类别 一抗 储存 冷冻（-20℃）
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 CCDC134
编 号 规格 库存 目录价（￥） 您的价格（￥） 数 量
D126174-0025 25 ul 现货 待询价 待询价
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D126174-0100 100 ul 现货 待询价 待询价
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D126174-0200 200 ul 现货 待询价 待询价
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产品描述

概述

In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657). Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657). May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808). May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808). In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.

应用

酶联免疫吸附测定（ELISA），免疫印迹（WB），免疫组织化学（IHC）

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q9H6E4
靶点基因 ID 79879
靶点全称 coiled-coil domain containing 134
靶点研究领域 Signal Transduction
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using D126174(CCDC134 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)


  • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using D126174(CCDC134 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200)


  • Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane 1-5: 293T, HepG2 cell, Human fetal liver tissue, Human liver tissue, TM4 cell lysates , Primary antibody: D126174(CCDC134 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute