Order NO. D145306
人CDH1重组蛋白（hFc tag C-Terminus）
| 英文名 | Human CDH1 Recombinant protein (hFc tag C-Terminus) | ||
| 别名 | cadherin 1; UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324 | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D145306-0010 | 10 UG | 预计5日内发货 |
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| D145306-0050 | 50 UG | 预计5日内发货 |
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| D145306-0100 | 100 UG | 预计5日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 23-706 amino acids of Human CDH1
属性
| Full name: | cadherin 1 |
| Synonyms: | UVO; CDHE; ECAD; LCAM; Arc-1; BCDS1; CD324 |
| Swissprot: | P12830 |
| Purity: | >95%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | HEK293 |
| Tags: | hFc tag C-Terminus |
| Species: | Human |
| Molecular mass: | The protein has a predicted molecular weight of 101.6 kDa after removal of the signal peptide. The apparent molecular weight of CDH1-hFc is approximately 100-130 kDa due to glycosylation. |
| Research areas: | Signal Transduction, Developmental Biology |
| Background: | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
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