Order NO. D145651
人IL17A重组蛋白（hFc tag C-Terminus）
| 英文名 | Human IL17A Recombinant protein (hFc tag C-Terminus) | ||
| 别名 | interleukin 17A; IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D145651-0010 | 10 UG | 预计5日内发货 |
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| D145651-0050 | 50 UG | 预计5日内发货 |
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| D145651-0100 | 100 UG | 预计5日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 24-155 amino acids of Human IL17A
属性
| Full name: | interleukin 17A |
| Synonyms: | IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A |
| Swissprot: | Q16552 |
| Purity: | >95%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | HEK293 |
| Tags: | hFc tag C-Terminus |
| Background: | This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. |
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