Order NO. D145709
人IL12B重组蛋白（6×His tag C-Terminus）
| 英文名 | Human IL12B Recombinant protein (6×His tag C-Terminus) | ||
| 别名 | interleukin 12B; CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B | ||
| 相关类别 | 抗原 | 储存 | 冷冻（-20℃） |
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D145709-0010 | 10 UG | 预计5日内发货 |
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| D145709-0050 | 50 UG | 预计5日内发货 |
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| D145709-0100 | 100 UG | 预计5日内发货 |
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产品描述
概述
Fusion protein corresponding to a region derived from 23-328 amino acids of Human IL12B
属性
| Full name: | interleukin 12B |
| Synonyms: | CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B |
| Swissprot: | P29460 |
| Purity: | >85%, as determined by Coomassie blue stained SDS-PAGE |
| Expression system: | HEK293 |
| Tags: | 6×His tag C-Terminus |
| Species: | Human |
| Molecular mass: | The protein has a predicted molecular weight of 35.5 kDa after removal of the signal peptide. The apparent molecular weight of IL12B-His is approximately 35-55 kDa due to glycosylation. |
| Research areas: | Immunology |
| Background: | This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. |
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