Order NO. D151312
产品描述
概述
The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2, leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. This protein is thought to modulate mitochondrial function. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome.
应用
免疫印迹(WB)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q9NZJ5
|
靶点基因 ID |
9451
|
靶点全称 |
eukaryotic translation initiation factor 2 alpha kinase 3
|
靶点别名 |
PEK; WRS; PERK
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Metabolism
|
亚型 |
Immunogen-specific rabbit IgG
|