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Order NO. D151366
兔抗MDC1(phospho-Ser513)多克隆抗体
英文名 Anti-MDC1 (phospho-Ser513) rabbit polyclonal antibody
别名 mediator of DNA-damage checkpoint 1; NFBD1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human
克隆类型 rabbit polyclonal 抗原 MDC1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D151366-0050 50 ul 预计5日内发货
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D151366-0100 100 ul 预计7日内发货
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D151366-0200 200 ul 预计7日内发货
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产品描述

概述

The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.

应用

免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q14676
靶点基因 ID 9656
亚型 Immunogen-specific rabbit IgG
靶点研究领域 Epigenetics and Nuclear Signaling
靶点别名 NFBD1
靶点全称 mediator of DNA-damage checkpoint 1
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using D151366(MDC1(Phospho-Ser513) Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)

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