Order NO. D151366
产品描述
概述
The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
应用
免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q14676
|
靶点基因 ID |
9656
|
亚型 |
Immunogen-specific rabbit IgG
|
靶点研究领域 |
Epigenetics and Nuclear Signaling
|
靶点别名 |
NFBD1
|
靶点全称 |
mediator of DNA-damage checkpoint 1
|