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Order NO. D151626
兔抗EPHA2/3/4(Ab-588/596)多克隆抗体
英文名 Anti-EPHA2/3/4 (Ab-588/596) rabbit polyclonal antibody
别名 EPH receptor A2/3/4; ECK; CTPA; ARCC2; CTPP1; CTRCT6/EK4; ETK; HEK; ETK1; HEK4; TYRO4/SEK; HEK8; TYRO1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human
克隆类型 rabbit polyclonal 抗原 EPHA2/3/4
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D151626-0050 50 ul 预计5日内发货 1100 1100
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D151626-0100 100 ul 预计7日内发货 1600 1600
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D151626-0200 200 ul 预计7日内发货 2500 2500
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产品描述

概述

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

应用

免疫印迹(WB),免疫荧光(IF)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P29317/P29320/P54764
靶点基因 ID 1969/2042/2043
靶点全称 EPH receptor A2/3/4
靶点别名 ECK; CTPA; ARCC2; CTPP1; CTRCT6/EK4; ETK; HEK; ETK1; HEK4; TYRO4/SEK; HEK8; TYRO1
靶点研究领域 Cardiovascular, Neuroscience, Signal Transduction
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: MCF7 cells lysate, Primary antibody: D151626(EPHA2/3/4(Ab-588/596) Antibody) at dilution 1/500 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

  • The image is immunofluorescence of A549 cells using D151626(EPHA2/3/4(Ab-588/596) Antibody) at dilution 1/100.

  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane: MCF7 cells lysate, Primary antibody: D151626(EPHA2/3/4(Ab-588/596) Antibody) at dilution 1/500 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

  • The image is immunofluorescence of A549 cells using D151626(EPHA2/3/4(Ab-588/596) Antibody) at dilution 1/100.
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