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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D151626-0050 | 50 ul | 预计5日内发货 |
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| D151626-0100 | 100 ul | 预计7日内发货 |
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| D151626-0200 | 200 ul | 预计7日内发货 |
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概述
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.
应用
免疫印迹（WB），免疫荧光（IF）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | P29317/P29320/P54764 |
| 靶点基因 ID | 1969/2042/2043 |
| 靶点全称 | EPH receptor A2/3/4 |
| 靶点别名 | ECK; CTPA; ARCC2; CTPP1; CTRCT6/EK4; ETK; HEK; ETK1; HEK4; TYRO4/SEK; HEK8; TYRO1 |
| 靶点研究领域 | Cardiovascular, Neuroscience, Signal Transduction |
| 亚型 | Immunogen-specific rabbit IgG |
