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Order NO. D153573
兔抗MAPK8/MAPK9/MAPK10(Ab-183/185)多克隆抗体
英文名 Anti-MAPK8/MAPK9/MAPK10 (Ab-183/185) rabbit polyclonal antibody
别名 mitogen-activated protein kinase 8/9/10; JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; JNK2; SAPK; p54a; JNK2A; JNK2B;
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 MAPK8/MAPK9/MAPK10
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D153573-0050 50 ul 预计5日内发货
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D153573-0100 100 ul 预计5日内发货
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D153573-0200 200 ul 预计5日内发货
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产品描述

概述

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK8 is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. MAPK9 targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. MAPK10 is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

应用

免疫印迹(WB)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P45983/P45984/P53779
靶点基因 ID 5599/5601/5602
靶点全称 mitogen-activated protein kinase 8/9/10
靶点别名 JNK; JNK1; PRKM8; SAPK1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; JNK2; SAPK; p54a; JNK2A; JNK2B; PRKM9; JNK-55; SAPK1a; JNK2BETA; p54aSAPK; JNK2ALPHA; JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK
靶点研究领域 Signal Transduction, Cancer, Immunology
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-2: 293 and Hela cells, Primary antibody: D153573(MAPK8/MAPK9/MAPK10 (Ab-183/185) Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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