Order NO. D155026
产品描述
概述
The protein encoded by BAD gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform.
应用
免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q61337
|
靶点基因 ID |
572
|
靶点全称 |
BCL2-associated agonist of cell death (Phospho-Ser136)
|
靶点别名 |
Bbc2; AI325008
|
靶点研究领域 |
Cancer
|
亚型 |
Immunogen-specific rabbit IgG
|