Order NO. D155084
产品描述
概述
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.
应用
免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q9UQL6
|
靶点基因 ID |
10014
|
靶点全称 |
histone deacetylase 5 (Phospho-Ser498)
|
靶点别名 |
HD5; NY-CO-9
|
靶点研究领域 |
Epigenetics and Nuclear Signaling, Cardiovascular, Signal Transduction
|
亚型 |
Immunogen-specific rabbit IgG
|