Order NO. D155146
产品描述
概述
NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.
应用
免疫印迹（WB），免疫组织化学（IHC），免疫荧光（IF）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
P19838
|
| 靶点基因 ID |
4790
|
| 靶点全称 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (Phospho-Ser927)
|
| 靶点别名 |
p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
|
| 靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Immunology
|
| 亚型 |
Immunogen-specific rabbit IgG
|
