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Order NO. D155158
兔抗MAPK8/MAPK9/MAPK10(phospho-Thr183/Tyr185)多克隆抗体
英文名 Anti-MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) rabbit polyclonal antibody
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 MAPK8/MAPK9/MAPK10
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D155158-0050 50 ul 预计5日内发货
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D155158-0100 100 ul 现货
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D155158-0200 200 ul 现货
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产品描述

概述

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

应用

免疫印迹(WB),免疫荧光(IF)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P45983/P45984/P53779
靶点基因 ID 5599/5601/5602
靶点全称 MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)
靶点别名 Stress-activated protein kinase JNK1 ; c-Jun N-terminal kinase 1; JNK-46
靶点研究领域 Signal Transduction, Cancer, Immunology
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 10%SDS-PAGE, Lysate: 30 μg, Lane 1-2: C6 cells treated with anisomycin , C6 cells untreated with anisomycin , Primary antibody: D155158(MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

  • The image is immunofluorescence of Hela cells using D155158(MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185) Antibody) at dilution 1/100.
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