Order NO. D155158
产品描述
概述
Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
应用
免疫印迹(WB),免疫荧光(IF)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P45983/P45984/P53779
|
靶点基因 ID |
5599/5601/5602
|
靶点全称 |
MAPK8/MAPK9/MAPK10 (phospho-Thr183/Tyr185)
|
靶点别名 |
Stress-activated protein kinase JNK1
; c-Jun N-terminal kinase 1; JNK-46
|
靶点研究领域 |
Signal Transduction, Cancer, Immunology
|
亚型 |
Immunogen-specific rabbit IgG
|