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Order NO. D155162
兔抗HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220)多克隆抗体
英文名 Anti-HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) rabbit polyclonal antibody
别名 HD4/HD5/HD9
相关类别 一抗 储存 冷冻(-20℃) 避光
宿主 Rabbit 反应种属 Human
克隆类型 rabbit polyclonal 抗原 HDAC4/HDAC5/HDAC9
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D155162-0025 25 ul 现货 880 880
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D155162-0100 100 ul 现货 1980 1980
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D155162-0200 200 ul 现货 3500 3500
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产品描述

概述

Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general,they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.

应用

免疫印迹(WB),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 P56524/Q9UQL6/Q9UKV0
靶点基因 ID 9759/10014/9734
靶点全称 HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220)
靶点别名 HD4/HD5/HD9
靶点研究领域 Epigenetics and Nuclear Signaling, Cardiovascular
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using D155162(HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane 1-2: 293 cells untreated with EGF , 293 cells treated with EGF , Primary antibody: D155162(HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute

  • The image on the left is immunohistochemistry of paraffin-embedded Human breast carcinoma tissue using D155162(HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)


  • Gel: 8%SDS-PAGE, Lysate: 30 μg, Lane 1-2: 293 cells untreated with EGF , 293 cells treated with EGF , Primary antibody: D155162(HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
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