Order NO. D155164
产品描述
概述
Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks.
应用
免疫印迹(WB),免疫组织化学(IHC),免疫荧光(IF)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P00519/P42684
|
靶点基因 ID |
25/27
|
靶点全称 |
ABL proto-oncogene 1, non-receptor tyrosine kinase/ABL proto-oncogene 2, non-receptor tyrosine kinase
|
靶点别名 |
ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; bcr/abl; ARG; ABLL
|
靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling, Cancer
|
亚型 |
Immunogen-specific rabbit IgG
|