Order NO. D155174
产品描述
概述
Participates in signal transduction in hematopoietic cells. Adapter protein that functions as a negative regulator of many signaling pathways that start from receptors at the cell surface. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including PDGFA, EGF and CSF1, and terminates signaling.
应用
免疫印迹(WB),免疫组织化学(IHC),免疫荧光(IF)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P22681
|
靶点基因 ID |
867
|
靶点全称 |
Cbl proto-oncogene, E3 ubiquitin protein ligase (phospho-Tyr700)
|
靶点别名 |
CBL2; NSLL; C-CBL; RNF55; FRA11B
|
靶点研究领域 |
Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Cell Biology
|
亚型 |
Immunogen-specific rabbit IgG
|