Order NO. D155275
产品描述
概述
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
应用
免疫印迹(WB)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
P13612
|
靶点基因 ID |
3676
|
靶点全称 |
integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
|
靶点别名 |
IA4; MGC90518; ITGA4; CD49D
|
靶点研究领域 |
Signal Transduction, Cardiovascular, Immunology, Stem Cells
|
亚型 |
Immunogen-specific rabbit IgG
|