概述

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

应用

免疫检测

属性

保存缓冲液	-20°C, 0.01M PBS (pH7.4). Avoid repeated freeze-thaw cycles.
运输条件	2-8°C
靶点 Uniprot 登记号	P05067
靶点基因 ID	351
靶点全称	amyloid beta precursor protein
靶点别名	amyloid beta precursor protein; Amyloid Beta 1-42; Aβ1-42; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; preA4; CTFgamma; alpha-sAPP; β淀粉样蛋白1-42
靶点研究领域	Neuroscience
亚型	IgG