Order NO. D160249
兔抗DDB1多克隆抗体
| 英文名 | Anti-DDB1 rabbit polyclonal antibody | ||
| 别名 | XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1 | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human, Mouse, Rat |
| 标记物 | Unconjugate | 克隆类型 | rabbit polyclonal |
| 抗原 | DDB1 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D160249-0025 | 25 ul | 现货 |
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| D160249-0100 | 100 ul | 现货 |
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| D160249-0200 | 200 ul | 现货 |
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属性
| Background: | The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012] (The background information is obtained from official databases and does not represent the product information.) |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | DDB1 |
| Immunogen: | Synthetic peptide of human DDB1 |
| Full name: | damage specific DNA binding protein 1 |
| Synonyms: | XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1; WHIKERS |
| SwissProt: | Q16531 |
| ELISA Recommended dilution: | 1000-5000 |
| IHC positive control: | Human cervical cancer |
| IHC Recommend dilution: | 25-100 |
| WB Predicted band size: | 127 kDa |
| WB Positive control: | Mouse eye tissue, Mouse brain tissue, Raji, A549, 293T, NIH/3T3 cell lysates |
| WB Recommended dilution: | 1000-5000 |
相关文档
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