Order NO. D161214
产品描述
概述
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U)GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2). Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
应用
酶联免疫吸附测定(ELISA),免疫印迹(WB),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q9NWB1
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靶点基因 ID |
54715
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靶点全称 |
RNA binding fox-1 homolog 1
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靶点别名 |
2BP1; FOX1; A2BP1; FOX-1; HRNBP1
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靶点研究领域 |
Epigenetics and Nuclear Signaling, Neuroscience, Developmental Biology
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亚型 |
Immunogen-specific rabbit IgG
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