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Order NO. D161228
兔抗ACVR1多克隆抗体
英文名 Anti-ACVR1 rabbit polyclonal antibody
别名 activin A receptor type I; FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 ACVR1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D161228-0025 25 ul 现货
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D161228-0100 100 ul 现货
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D161228-0200 200 ul 现货
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产品描述

概述

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

应用

酶联免疫吸附测定(ELISA),免疫印迹(WB)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q04771
靶点基因 ID 90
靶点全称 activin A receptor type I
靶点别名 FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2
靶点研究领域 Signal Transduction, Epigenetics and Nuclear Signaling
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: NIH/3T3 and HUVEC cell lysates, Primary antibody: D161228(ACVR1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes
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