Order NO. D161273
产品描述
概述
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
应用
酶联免疫吸附测定(ELISA),免疫组织化学(IHC)
属性
保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
运输条件 |
2-8°C
|
靶点 Uniprot 登记号 |
Q13131
|
靶点基因 ID |
5562
|
靶点全称 |
protein kinase, AMP-activated, alpha 1 catalytic subunit
|
靶点别名 |
AMPK; AMPKa1
|
靶点研究领域 |
Signal Transduction, Cancer, Metabolism, Cardiovascular, Neuroscience
|
亚型 |
Immunogen-specific rabbit IgG
|