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Order NO. D161452
兔抗SMAD1多克隆抗体
英文名 Anti-SMAD1 rabbit polyclonal antibody
别名 BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
相关类别 一抗 储存 冷冻(-20℃)
宿主 Rabbit 反应种属 Human, Mouse, Rat
克隆类型 rabbit polyclonal 抗原 SMAD1
   
编 号 包装 库存 目录价(¥) 您的价格(¥) 数 量
D161452-0025 25 ul 现货
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D161452-0100 100 ul 现货
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D161452-0200 200 ul 现货
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产品描述

概述

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.

应用

酶联免疫吸附测定(ELISA),免疫组织化学(IHC)

属性

保存缓冲液 -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
运输条件 2-8°C
靶点 Uniprot 登记号 Q15797
靶点基因 ID 4086
靶点全称 SMAD family member 1
靶点别名 BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1
靶点研究领域 Signal Transduction, Epigenetics and Nuclear Signaling, Cancer, Cardiovascular
亚型 Immunogen-specific rabbit IgG
相关文档
Sample Application

  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using D161452(SMAD1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)

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