Order NO. D161497
产品描述
概述
This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins. Some of the predicted proteins may not produce functional ion channel subunits.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 |
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
|
| 运输条件 |
2-8°C
|
| 靶点 Uniprot 登记号 |
Q13936
|
| 靶点基因 ID |
775
|
| 靶点全称 |
calcium channel, voltage-dependent, L type, alpha 1C subunit
|
| 靶点别名 |
TS; LQT8; CACH2; CACN2; CaV1.2; CCHL1A1; CACNL1A1
|
| 靶点研究领域 |
Signal Transduction, Cancer, Metabolism, Neuroscience, Cardiovascular
|
| 亚型 |
Immunogen-specific rabbit IgG
|
