Order NO. D162068
兔抗PMS2多克隆抗体
| 英文名 | Anti-PMS2 rabbit polyclonal antibody | ||
| 别名 | PMSL2; HNPCC4; PMS2CL | ||
| 相关类别 | 一抗 | 储存 | 冷冻（-20℃） |
| 宿主 | Rabbit | 反应种属 | Human |
| 标记物 | Unconjugate | 克隆类型 | rabbit polyclonal |
| 抗原 | PMS2 | ||
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| 编 号 | 包装 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D162068-0025 | 25 ul | 现货 | 500 | 500 |
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| D162068-0100 | 100 ul | 现货 | 1600 | 1600 |
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| D162068-0200 | 200 ul | 现货 | 2500 | 2500 |
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属性
| Background: | The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. (The background information is obtained from official databases and does not represent the product information.) |
| Applications: | ELISA, WB, IHC |
| Name of antibody: | PMS2 |
| Immunogen: | Synthetic peptide of human PMS2 |
| Full name: | PMS1 homolog 2, mismatch repair system component |
| Synonyms: | MLH4; PMS-2; PMSL2; HNPCC4; LYNCH4; MMRCS4; PMS2CL |
| SwissProt: | P54278 |
| ELISA Recommended dilution: | 5000-10000 |
| IHC positive control: | Human prostate cancer |
| IHC Recommend dilution: | 50-100 |
| WB Predicted band size: | 96 kDa |
| WB Positive control: | Hela cell lysate |
| WB Recommended dilution: | 1000-5000 |
相关文档
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Sample Application
