精确搜索
我的草稿
我的购物车
精确搜索
询价单号 点击跳转查看 X
| 编 号 | 规格 | 库存 | 目录价（￥） | 您的价格（￥） | 数 量 |
| D162786-0025 | 25 ul | 现货 | 待询价 | 待询价 |
|
| D162786-0100 | 100 ul | 现货 | 待询价 | 待询价 |
|
| D162786-0200 | 200 ul | 现货 | 待询价 | 待询价 |
|
概述
This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.
应用
酶联免疫吸附测定（ELISA），免疫组织化学（IHC）
属性
| 保存缓冲液 | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 运输条件 | 2-8°C |
| 靶点 Uniprot 登记号 | Q9H2X3 |
| 靶点基因 ID | 10332 |
| 靶点全称 | C-type lectin domain family 4, member M |
| 靶点别名 | CD299; LSIGN; CD209L; L-SIGN; DCSIGNR; HP10347; DC-SIGN2; DC-SIGNR |
| 靶点研究领域 | Cardiovascular, Immunology |
| 亚型 | Immunogen-specific rabbit IgG |
结算方信息确认
申请授权
请填写负责人信息
